br Conclusion br To our
To our knowledge, this Hexa His tag peptide is the largest study examining the
relationship between occupational exposure to alkylphenolic com-pounds and breast and prostate cancer. We examined these associations using a method that considered relevant changes over time in the use of these compounds, and we adjusted for multiple potential confounding variables. Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, while no association with prostate cancer. The elucidation of the role of alkylphenolic compounds on breast and prostate cancers should shed a light on the etiology of those tumors and help informing future public health decisions.
Conflicts of interest
The authors have no conflict of interests to declare.
We appreciate the collaboration of all those who participated pro-viding questionnaire data. We also thank Laia Alemany, Claudia Robles, Emilia Molinero-Ruiz, Nereida Gras, Santos Hernández, and Ferran Calduch for their helpful contributions. We thank all MCC-Spain study group members and collaborators.
Appendix A. Supplementary data
P. Peremiquel-Trillas et al.
Bontje, D., Hermens, J., Vermeire, T., Damstra, T., 2004. United Nations Environment Programme. International Labour Organisation. International Programme on Chemical Safety. Integrated Risk Assessment: Nonylphenol Case Study. WHO/IPCS/ IRA/12/04.
Casals-Casas, C., Desvergne, B., 2011. Endocrine disruptors: from endocrine to metabolic
Damstra, T., Barlow, S., Bergman, A., Kavloc, R., Van Der Kraak, G., 2002. Global Assessment of the State-of-the-Science of Endocrine Disruptors: An Assessment Prepared by an Expert Group on Behalf of the World Health Organization, the International Labour Organisation, and the United Nations Environment Programme. World Health Organization.
Nonylphenol and bisphenol A in Swedish food and exposure in Swedish nursing women. Environ. Int. 43, 21–28. https://doi.org/10.1016/j.envint.2012.02.010. Hansen, Munn, De Bruijn, Pakalin, Luotarno, Berthault, Vegro, Heidorn, Pellegrini, Vormann, Allanou, Scheer, 2002. European Union risk assessment report: 4-non-ylphenol (branched) and nonylphenol. In: Inst. Health Consum. Prot. Eur. Chem. Bur. 10.
Evidence that estrogens directly alter androgen-regulated prostate development.
Kauppinen, T., 1996. Exposure assessment - a challenge for occupational epidemiology.
Lassen, C., Jensen, A.A., Maag, J., Christensen, F., Kjolholt, J., Jeppesen, C.N., Mikkelsen, S.H., Innanen, S., 2013. Survey of Alkylphenols and Alkylphenol Ethoxylates. Part of the LOUS-review. The Danish Environmental Protection Agency, Copenhagen, Denmark.
Le Moual, N., Bakke, P., Orlowski, E., Heederik, D., Kromhout, H., Kennedy, S.M., Rijcken, B., Kauffmann, F., 2000. Performance of population specific job exposure matrices (JEMs): European collaborative analyses on occupational risk factors for chronic obstructive pulmonary disease with job exposure matrices (ECOJEM). Occup. Environ. Med. 57, 126–132.
(Halichoerus grypus) fur and herring gull (Larus argentatus) feathers as accumulators
Estrogenic effects of environmental chemicals: an interspecies comparison. Comp.
Pearce, N., Checkoway, H., Kriebel, D., 2007. Bias in occupational epidemiology studies.
Lippincott Williams Wilkins, Phila. PA.
P. Peremiquel-Trillas et al.
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Allocation of excessive cancer risk induced by benzene inhalation in 11 cities of Europe in atmospheric circulation regimes
Konstantinos Dimitriou∗, Pavlos Kassomenos
Laboratory of Meteorology, Department of Physics, University of Ioannina, Greece
Incremental Lifetime Cancer Risk Atmospheric circulation Air quality
Daily atmospheric concentrations of benzene, measured during the years 2008–2012 in 11 European cities, were analyzed in terms of atmospheric circulation. Benzene levels in central continental Europe and Northern Europe were clearly enhanced by extended anticyclones located over North West Russia (NWR), whereas weak gradient conditions, which are associated with light winds, were connected with the degradation of air quality across Southern Europe due to recirculation of polluted air. The calculated Incremental Lifetime Cancer Risk (ILCR) indicated potential health risks for humans due to the inhalation of benzene at all areas, whilst not re-commendable ILCR values were detected at all traﬃc sites. The estimated ILCR was also allocated in the pro-duced atmospheric circulation regimes, based on an approach which took into account the average benzene concentration corresponding to each synoptic pattern along with its frequency of occurrence. Synoptic regimes associated with increased benzene levels commonly accounted for large fractions of the total risk however in some cases the impact of highly polluted atmospheric regimes on ILCR was reduced, due to the lack of ap-pearance of these atmospheric circulation types.