E 64 Meta Gene br polymorphism in Asian
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polymorphism in Asian women in two important studies done on Asian women, and thus increased risk of SULT1A1 polymorphism in breast cancer was seen (Jiang et al., 2010; Kotnis et al., 2008). A meta-analysis revealed strong association of SULT1A1 with breast cancer in Asian population and reported the gene to be a very useful biomarker for identifying high-risk patients (Forat-Yazdi et al., 2017). The result of the present study was similar to the two studies conducted in South India (Chacko et al., 2004; Kumar et al., 2013). Taking into con-sideration the variable factors influencing the cancer risk, such as en-vironmental carcinogens, life style, food habits, and ethnicity (Rastogi et al., 2004), it is necessary to perform such association-determining studies with respect to the Indian population. Functionally relevant polymorphisms of candidate genes in xenobiotic and estrogen-meta-bolizing pathway were found to contribute to different risk for different population. Hence it is important to replicate the studies to validate the variant factors as being of risk for breast cancer in the Indian popula-tion. The inconsistency of the previous studies may be due to racial differences, difference in study number, and interethnic differences. The genetic material is the target for metabolites released from meta-bolic pathways, environmental carcinogens, endogenous and exo-genous hormones, and physical agents. The interindividual differences and interethnic differences in pharmacological and toxicological influ-ence are due to the variants present in the functional allele in an in-dividual and in a particular population. This study sheds light on the association of rs4646903 and rs9282861 polymorphism with breast cancer risk, as it is needed to replicate studies to validate a poly-morphism as risk marker for breast cancer. The data obtained have a potential application toward personalized approach and translational medicine in the management of breast cancer patients.
The study revealed statistically significant association of the two polymorphism, rs4646903 of CYP1A1 gene and rs9282861 of SULTIA1 gene, with breast cancer risk in an Indian population. Thus, the inter-action between genetic polymorphisms of the genes of metabolic acti-vation and deactivation pathway of environmental toxicants and es-trogens merits investigations. A tight balanced regulation of activation and deactivation E 64 are needed, and high or low activity has the potential to be curative.
Intramural Research Grant GATE for the funding.
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