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br previously expounded The presence of
2020-08-02
previously expounded. The presence of native CPT may have led to saturation of cellular internalization of CPT, leading to rapid killing of cells in the S-phase of the cell cycle. However, the short duration of the cytotoxic stress presented by CPT had a marginal effect on cells in other phases of
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br fold molar excess of unlabeled estradiol was
2020-08-02
100-fold molar excess of unlabeled estradiol-17β was present in paired samples to determine displaceable binding [41]. Competitive ligand binding to ER-positive MCF-7 Moniliformin is detected by the ability of a test compound to displace labeled estradiol-17β from the cells in vitro. 2.6. E
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br Tumor associated inflammation is involved in aggressivene
2020-07-29
Tumor-associated inflammation is involved in aggressiveness and metastatic progression in several types of cancer [20], including pros-tate cancer [21,22]. It has been suggested that inducing the expressions of inflammatory response genes may contribute to the development of prostate cancer. Prost
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br To investigate the e ects
2020-07-28
To investigate the effects of SNRPA1 knocking down on the cells’ proliferation abilities, we applied the Celigo cell proliferation assay to RKO and HCT116 KRN 7000 transduced with anti-SNRPA1 shRNA or control Biomedicine & Pharmacotherapy 117 (2019) 109076 lentivirus 3 days before the experi
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b http www glpbio com simage
2020-07-27
r> Since the first graphene-based biosensor was reprted by Shan et al. [12], a variety of nanoplatforms have been developed using the graphene nanocomposites for the sensing of biological com-pounds [13–15]. In this work, we reported an acid-base bifunctional rGO by introducing L-histidine, as an e
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br Conclusion br To our
2020-07-06
5. Conclusion To our knowledge, this Hexa His tag peptide is the largest study examining the relationship between occupational exposure to alkylphenolic com-pounds and breast and prostate cancer. We examined these associations using a method that considered relevant changes over time in
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br Prior studies reported inconsistent
2020-07-04
Prior studies reported inconsistent effects of ACA implementation on cancer stage at diagnosis (Han et al., 2018; Han et al., 2016; Jemal et al., 2017; Robbins et al., 2015; Sabik and Adunlin, 2017; Smith and Fader, 2018; Soni et al., 2018). Studies that reported increased early stage diagnosis pri
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br Introduction br Prostate cancer is
2020-07-04
1. Introduction Prostate cancer is the second most common cancer in human males and is the second leading cause of cancer-related death in American males. Androgen receptor (AR)-mediated gene transcription in the target tissue is critical to the proliferation and progression of PCa (Dai et al.,
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br References br Fredriksson S Gullberg M Jarvius J
2020-03-17
References [10] Fredriksson S, Gullberg M, Jarvius J, Olsson C, Pietras K, Gústafsdóttir SM, et al. Pro-tein detection using proximity-dependent DNA ligation assays. Nat Biotechnol 2002; 20:473–7. https://doi.org/10.1038/nbt0502-473. [11] Lundberg M, Eriksson A, Tran B, Assarsson E, Fredriksso
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B Effect of wogonoside on VEGF expression in xenograft
2020-03-17
(B) Effect of wogonoside on VEGF expression in xenograft model of MDA-MB-231 cells in nude mice (n = 5) was detected by western blot analysis. (C) The expression of VEGF in xenograft model was detected by immunochemistry using specific antibody. (D) The concentration of VEGF in MDA-MB-231 and
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B br surgery br Odds Ratio br Odds Ratio
2020-03-17
B [surgery] Odds Ratio Odds Ratio Study or Subgroup log [Odds Ratio] SE Weight IV, Random, 95% CI Favours Favours C [surgery] FIGURE 1. Forest plot of the OR of overall survival in unmatched patients (A), overall survival in matched patients (B), and cancer-specific su
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br Fig CLSM images of MCF cells treated with
2019-10-22
Fig. 10. CLSM images of MCF-7 2-Guanidinoethylmercaptosuccinic Acid treated with DHHC-GNRAH + NIR and DOX-DHHC-GNRAH + NIR. The lower left half of each well of culture plates was exposed to NIR irradia-tion, and the upper right half was kept in the dark. Viable cells were stained green with calce
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br where Xi is the amount
2019-10-22
where Xi is the amount initially loaded into NCs and Xt the amount that is in NCs at time point. As drug released was below the detection limit, by measuring the drug retained within NCs, the amount of drug re-leased could be indirectly calculated. The small amount discarded at each time point whe
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br Cell lines and culture conditions br
2019-10-21
Cell lines and culture conditions Human NSCLC cells A549 and non-cancer lung fibroblast cells MRC-5 were originally purchased from Cell Bank of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (Shanghai, China). It was cultured in RPMI-1640 (Corning) medium containing 10
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br Based on the difference between mitochondria from cancer
2019-10-21
Based on the difference between mitochondria from cancer cells and those from normal cells, a large amount of antitumor agents acting directly on mitochondria have been researched and developed. A part of these agents trigger mitochondria-mediated apoptosis via inhibition of Bcl-2/Bcl-xL or activa