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br regions UTR of targeted mRNAs using miRNA response
2019-10-21
regions (3′-UTR) of targeted mRNAs using miRNA response elements (MRE) to exhibit their posttranscriptional regulatory effects [32]. Computational searches performed in circRNAs for miRNAs Artesunate revealed that many circRNAs contain MREs, indicating that cir-cRNAs may act as miRNAs sponge, decre
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br To evaluate whether the inhibition
2019-10-21
To evaluate whether the inhibition of cell proliferation by [email protected] NPs was due to the induction of apoptosis, cell apoptosis was evaluated by calcein-AM/PI double staining (Fig. 3D). More apoptotic cells were observed upon treatment with [email protected] NPs than with free DOX or OA treatmen
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Pain Skin changes Fatigue br Aggregated data
2019-10-17
Pain Skin changes Fatigue Aggregated data based on neutrosophic scale. Step 10. Begin to rank alternatives (diseases) using NSAW as follows: - Use five point scale which presented in Table 4 and construct decision matrix of alternatives according to each criterion. Aggregate experts opini
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br were topologically important for
2019-10-16
were topologically important for connecting the DM genes on the PPI network. Finally, a random-walk based machine learning method was developed to propagate the DNA methylation scores from the DM genes to ECs, and the derived scores for the EC genes were used to con-struct a support vector mach
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ITF2357 (Givinostat) br The overall response rate of chemoth
2019-10-14
The overall response rate of chemotherapeutic chemical drugs for CRC such as 5-fluorouracil, oxaliplatin and CPT-11 has a very narrow therapeutic window because of their severe toxicity [38]. Therefore, a potential way to improve the therapeutic efficacy and limit their ad-verse effects is a combinat
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br Anti BrdU APC br Anti Annexin V APC
2019-10-14
Anti-BrdU-APC Anti-Annexin V-APC Bacterial and Virus Strains Chemically competent One shot Stbl3 Biological Samples Patient-derived pancreatic cancer Moores Cancer Center, N/A xenografts and organoid lines University Y-27632 California San Diego Chemicals, Peptides, and
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br b National Institute of Oncology Centre of
2019-10-08
b National Institute of Oncology, Centre of Radiotherapy, Rath Gyorgy€ Str. 7-9. 1122, Budapest, Hungary c Semmelweis University, Department of Oncology, Rath Gyorgy€ Str. 7-9. 1122, Budapest, Hungary d National Institute of Oncology, Department of Molecular Genetics, Rath Gyorgy€ Str. 7-9.
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br The gene signature outperformed
2019-10-07
3.3. The 15-gene signature outperformed conventional diagnostic approaches for LN metastasis detection in gastric cancer patients Using multivariate analysis, we demonstrated that our 15-gene sig-nature was able to successfully detect LN metastasis, independent of pre-operative clinical factors
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br Concordance between Rac and S pBcl expression in clinical
2019-10-03
3.6. Concordance between Rac1 and S70pBcl-2 expression in clinical lymphomas 3.7. Increased levels of Rac1 and S70pBcl-2 are associated with advanced stage lymphomas Based on the expression analyses of Rac1, Bcl-2 and S70pBcl-2 in 34 patient lymphoma samples, we proceeded to explore the cros
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br Fig Feature Selector Stability a
2019-09-28
Fig. 7. Feature Selector Stability: (a) Jaccard index for Feature Subsets with different cardinality; (b) MDS plot of the Feature Ranking Algorithms. Table 5 Top-40 Pearson and top-41 SVM-Wrapper feature sets. Ranker Pearson SVM-wrapper Rank Classifier LR SVM Level of education
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br We also performed unweighted Cox regressions for pa tient
2019-09-26
We also performed unweighted Cox regressions for pa-tient subgroups defined by Gleason grade, clinical T-stage, NCCN risk category (intermediate, high), and androgen deprivation therapy use. For the NCCN risk category sub-group, Gleason grade, clinical T-stage, and PSA were not included in the mod
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br tained using a Hamamatsu NanoZoomer with
2019-09-24
tained using a Hamamatsu NanoZoomer with 40X magnifica- tion (0.5 μm resolution) and downsampled to approximately biomarkers: MSH2 All sections were obtained from previous clinical studies. All tis- (20) sue sections underwent immunohistochemical staining using dif- ferent prot
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br Results and discussion br Synthesis
2019-09-23
2. Results and discussion 2.1. Synthesis and characterization of the nanoplatform Fig. 1a shows a schematic summary of the detailed synthesis of the nanoplatform. Hollow MnSiO3 nanoparticles were synthesized based on well-dispersed Mesoporous silica nanoparticles (MSNs). Then, Fe3O4 nanopart
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br For the cervical cancer dataset finding the representativ
2019-09-23
For the cervical cancer dataset [18], finding the representative patterns from the complete data is a non-trivial task. The major di culties can be summarized as follows: 1. Noise and uncertainty in data collection: Owing to some subjective (e.g., misremembering certain information) and objecti
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br Besides the limited number
2019-09-23
Besides the limited number of patients included and the rather short follow-up, our study is also limited by the fact that Iberiotoxin the administered dose of 99mTc-PSMA-I&S, and the time interval between application and surgery have been chosen empirically and were not evaluated in detail.