• br improved progression free survival

  2019-09-23

  

  improved progression-free survival was much lower in HR-proficient cancers than in ovarian cancers with a positive HRD score. In contrast, in the present study where the endpoint was tumor shrinkage, responses to ABT-767 were only observed in HR-deficient cancers (Fig. 3A). Even so, the numerical

• Schonberg MA Marcantonio ER Li D et al Breast

  2019-09-16

  

  [21] Schonberg MA, Marcantonio ER, Li D, et al. Breast cancer among the oldest old: tumor characteristics, treatment choices, and survival [Internet]. J Clin Oncol 2010;28: 2038–45 Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860406/. [22] Petkov VI, Miller DP, Howlader N, et al. Bre

• Redox Biology xxx xxxx xxxx br Contents lists

  2019-09-16

  

  Redox Biology xxx (xxxx) xxxx Contents lists available at ScienceDirect Redox Biology journal homepage: www.elsevier.com/locate/redox Research Paper 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression Eun Ji Leea,b, Su-Jung Kim

• br Introduction Hepatocyte Growth Factor HGF and

  2019-08-26

  

  Introduction Hepatocyte Growth Factor (HGF) and its receptor cellular Mesenchymal Epithelial Transition factor (c-MET), a heterodimeric tyrosine kinase receptor, are frequently expressed in non-small cell lung cancer (NSCLC) and represents an oncogenic signaling pathway of major interest in NSCLC

• JNJ-42153605 We found a low NPV for EBUS TBNA

  2019-08-26

  

  We found a low NPV (56%) for EBUS-TBNA in centrally located lung lesions. These data are in line with other case series, which reported values ranging between 23% and 75% [[10], [11], [12], [13], [14], [15]]. This value, however, is likely to be influenced by the high prevalence of malignancy (92.4%

• br Funding Research grant support was provided by Guardant H

  2019-08-26

  

  Funding Research grant support was provided by Guardant Health Inc. for plasma-based comprehensive genomic testing, grant number C16/12/00442. Disclosures Introduction A variety of culture systems have been developed previously to examine cancer biology, among which two-dimensional (2D) sy

• CFTRinh-172 Fig shows a possible first

  2019-08-26

  

  Fig. 1 shows a possible first-line treatment algorithm for advanced non-squamous NSCLC. The KEYNOTE-189 trial provided solid data for pembrolizumab plus pemetrexed/(cis)carboplatin demonstrating a significant PFS and OS benefit over ChT with a HR of 0.49 and a benefit consistency across all PD-L1 su

• Theoretically p Ki co expression is related to HPV infection

  2019-08-26

  

  Theoretically, p16/Ki-67 co-expression is related to HPV infection. HPV virus—especially HPV 16/18—interferes with the cell regulation mechanism through Diphenylterazine (DTZ) of its DNA into the DNA of the host cell [25,26]. The abnormal cell then expresses p16 and Ki-67 simultaneously, transformin

• The association between CCS and migration

  2019-08-16

  

  The association between CCS and Ko 143 status was not explained away by the range of confounding factors included in our model, one of which was a detailed measure of SES. We could not account for important factors that could be more prevalent among women of foreign origin and that might account fo

• br Similar and dissimilar expression profiles of

  2019-08-16

  

  Similar and dissimilar Chloramphenicol profiles of miRNAs in the saliva/WMF and serum/plasma of OSCC patients Several miRNAs are reported to show similar concentrations in different body fluids of OSCC patients. For example, miR-24, miR-146a, miR-184, miR-31, miR-451 and miR-26a have been report

• Clinical studies often employ restrictive inclusion and

  2019-08-16

  

  Clinical studies often employ restrictive inclusion and exclusion criteria that inevitably lead to patient selection. Indeed, in line with Mengis et al. [6] the most frequently noted reason for non-inclusion into a clinical trial was, in addition to patient choice, the exclusion criteria of the clin

• Our proposal is to calculate P

  2019-08-16

  

  Our proposal is to calculate P-values exactly without approximation, using this simulated data. This is in fact an old concept for rank statistics such as the Wilcoxon rank sum statistic, where published tables have long been available for use with data from studies involving very small sample sizes

• br Conflicts of interest br Author contribution statement

  2019-08-16

  

  Conflicts of interest Author contribution statement Acknowledgments Fundingwas provided by Alex’s Lemonade Stand Foundation. Introduction The TNM-Staging System (“Tumor, node and metastasis”) of the “International Union for Cancer Central (UICC)” [1] and the „American Joint Committee on

• One of the patients in this

  2019-07-24

  

  One of the patients in this study was observed to have a mutation in the GCK gene. GCK phosphorylates glucose, producing glucose-6-phosphate and facilitating glucose storage (as glycogen) as well as its disposal via glycolysis in hepatocytes. Glycolysis mediates an increase in ATP and a decrease in

• An important landmark in CF research has been the

  2019-07-08

  

  An important landmark in CF research has been the cloning of the CFTR gene in 1989 [16]. Soon later, several CF mutant mouse models were generated [17]. Initially researchers concentrated their efforts on the production of null mice by deleting specific portions of the murine homolog gene to CFTR (c

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